Aging Health Sciences
MaculaPM® Nighttime Eye Support
$57.99
Science-based · Doctor-derived · University-researched
MaculaPM® — Nighttime eye support formulated around retinal signaling and circadian biology.
While you sleep, the eye performs its most important maintenance and renewal processes. MaculaPM® is a once-nightly formula built around this biology — combining L-DOPA, melatonin, and key macular nutrients selected for their roles in retinal signaling, nighttime circadian function, and macular support.†
Developed by researchers at the University of Arizona. Backed by US patents 11,969,401 and 9,173,862. 60 capsules — 60-day supply.
What's inside — 6 evidence-based ingredients
L-DOPA (from Mucuna pruriens seed extract) — 100 mg
Supports retinal signaling through the GPR143 receptor in the retinal pigment epithelium. Involved in both pigment biology and retinal maintenance.
Melatonin — 5 mg
A naturally occurring hormone that regulates circadian rhythm, aligning the formula with the eye's overnight maintenance and renewal cycle.
Lutein (from Tagetes erecta L. flower) — 5 mg
Concentrates in the macula to help filter high-energy blue light and support macular pigment optical density. Included at doses studied in AREDS clinical trials.†
Zeaxanthin (from Tagetes erecta L. flower) — 2 mg
Works alongside lutein in the fovea to support central vision and macular pigment. Also studied in AREDS clinical trials.†
Vitamin C (as Ascorbic Acid) — 100 mg
An antioxidant that helps support the body's natural defenses against oxidative stress in retinal cells. Included in the AREDS clinical formula.
Vitamin E (as D-Alpha Tocopheryl Acid Succinate) — 35 mg
Supports antioxidant defense in photoreceptor cell membranes and retinal tissue. Part of the AREDS clinical trial evidence base.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
MaculaPM® Nighttime Eye Support
Just $0.82 a night with Subscribe & Save
- One capsule at bedtime · 60-night supply
- Skip or cancel your subscription anytime
- Made in the USA · Two US patents
The only eye supplement built around what your eyes actually do while you sleep.
While you rest, your retina goes to work — renewing, recycling, and maintaining the cells that power your vision. MaculaPM® is formulated around that biology.
Six evidence-based ingredients. One nightly capsule.
- L-DOPA (from Mucuna pruriens) supports retinal signaling through the GPR143 pathway — a mechanism most eye supplements don’t address.
- Melatonin aligns the formula with your eye's natural overnight renewal cycle.
- Lutein & Zeaxanthin help support macular pigment and filter high-energy blue light.
- Vitamins C & E provide antioxidant support for retinal cells.
Developed by University of Arizona researchers. Backed by two US patents. Doctor-derived, science-based, university-researched.
†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Take 1 capsule nightly, before bed.
Timing isn't arbitrary, it's the point. Your retina does its most important maintenance work while you sleep. MaculaPM® is formulated around that window, combining melatonin (which signals your body to begin overnight renewal) with L-DOPA and macular nutrients that support the eye's natural nightly biology. Think of it less like a supplement you remember to take, and more like a biological cue you set every night.
Shipping: Orders ship from the USA. Estimated delivery dates are shown at checkout.
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Estimated delivery between October 20 and October 22. Order within .
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- University-researchedLicensed through Tech Launch Arizona
- Two US patents11,969,401 · 9,173,862
- Ophthalmologist-ledFormer Chairman of Ophthalmology, U of A
- Made in the USA60 capsules · 60-night supply
How it works
One capsule, timed to your eye's overnight renewal.
Taken at bedtime, MaculaPM® delivers its nutrients as your retina shifts from daytime seeing to nighttime maintenance.*
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01Bedtime
Melatonin sets the clock
Melatonin is your body's natural nighttime signal. It aligns the formula with the eye's overnight maintenance cycle.*
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02Overnight
L-DOPA activates GPR143
L-DOPA is the only known natural activator of GPR143, a receptor on the RPE cells that look after your photoreceptors. MaculaPM® supplies it from Mucuna pruriens seed extract.*
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03While you sleep
The RPE does its nightly work
RPE cells process and recycle photoreceptor material overnight. MaculaPM® supports the signaling behind this routine maintenance.*
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04All day
Built-in daytime defense
Lutein and zeaxanthin concentrate in the macula and help filter high-energy blue light. Vitamins C and E add antioxidant support.*
Each RPE cell supports approximately 30 photoreceptors, recycling worn material from them every single night.
What's inside
Six ingredients. Clear doses. One capsule.
Every amount below matches the Supplement Facts label. Nothing is hidden in a proprietary blend.
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Patented approach
L-DOPA
100 mgFrom 200 mg Mucuna pruriens seed extract
Supports retinal signaling through the GPR143 receptor in the retinal pigment epithelium.*
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Melatonin
5 mgYour body's nighttime hormone. Aligns the formula with the eye's overnight maintenance and renewal cycle.*
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Lutein
5 mgFrom marigold flower (Tagetes erecta)
Concentrates in the macula to help filter high-energy blue light and support macular pigment.*
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Zeaxanthin
2 mgFrom marigold flower (Tagetes erecta)
Works alongside lutein in the center of the macula to support central vision.*
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Vitamin C
100 mgAs ascorbic acid
An antioxidant that helps support the body's natural defenses against oxidative stress in retinal cells.*
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Vitamin E
35 mgAs d-alpha tocopheryl acid succinate
Supports antioxidant defense in photoreceptor cell membranes.*
Other ingredients: microcrystalline cellulose, hydroxypropyl methylcellulose, maltodextrin, sucrose, plant gelatin, vegetable magnesium stearate, modified food starch, starch, silica. Manufactured in the USA.
Customer reviews
What customers are saying
Real reviews from verified MaculaPM® customers.
The team
Developed by eye scientists, not a marketing department.
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Robert W. Snyder, MD, PhD
Chief Clinical Officer
Ophthalmologist and surgeon with over 40 years of clinical experience. Former Chairman of Ophthalmology at the University of Arizona.
Read bio : Robert W. Snyder, MD, PhD -
Murray H. Brilliant, PhD
VP Research
Professor of Ophthalmology at the University of Arizona. 40 years in genetic research. Led the research on L-DOPA's role in the eye.
Read bio : Murray H. Brilliant, PhD -
Brian McKay, PhD
Lead Researcher
University of Arizona ophthalmology researcher whose work helped establish L-DOPA as the natural ligand for GPR143.
Read bio : Brian McKay, PhD -
John A. Martens
Formulation Scientist
Chemical engineer and chemist. 35 years as a corporate scientist at 3M, bringing rare formulation rigor to every capsule.
Read bio : John A. Martens
Can I take MaculaPM® with my current eye vitamin?
Yes. MaculaPM® is formulated to be taken alongside other eye supplements, including AREDS-style formulas, and a daily multivitamin. It adds nighttime support that standard formulas don't include.*
Why do I take it at night?
Your retina does most of its maintenance and renewal while you sleep. MaculaPM® is timed to that cycle, and it contains melatonin, your body's natural nighttime signal. Take one capsule before bed with a glass of water.
What is L-DOPA? Is it a drug?
L-DOPA is a naturally occurring compound. Your body makes it, including the pigment cells in your eye. In MaculaPM® it comes from the seed of Mucuna pruriens, a tropical legume, at 100 mg per capsule. MaculaPM® is a dietary supplement, not a drug.
Are there side effects or interactions?
MaculaPM® is generally well tolerated. Because it contains melatonin, some people feel drowsy, which is why it is taken at bedtime. Melatonin may interact with sedative medications, and L-DOPA may interact with some prescription medications. If you take other medications, are pregnant or nursing, or have a medical condition, talk with your doctor before use.
How long should I take it?
MaculaPM® is designed as a nightly habit. Like any nutritional support, it's meant to be taken consistently over time. That's why most customers choose Subscribe & Save, so they never run out.
How does Subscribe & Save work?
You save 15% on every bottle and a new 60-night supply ships every 60 days. You can skip a delivery or cancel anytime from your account.
Is this a replacement for seeing my eye doctor?
No. MaculaPM® is a dietary supplement intended to support macular and retinal health.* It is not a substitute for professional eye care, regular exams, or any treatment your provider recommends.
