Science-based eye health

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A science-driven, doctor-derived supplement formulated to support macular and retinal health while you rest and recharge at night.*

MaculaPM® Nighttime Eye Support One capsule nightly · from $0.82 a night
Two US patents
  • Doctor-derivedUniversity of Arizona eye researchers
  • Patented formulaUS 11,969,401 · 9,173,862
  • Once nightly60 capsules · 60-night supply
  • Six evidence-based ingredientsClear doses, no proprietary blend

Day and night

The eye's most important work happens while you sleep

Your eyes work hard all day. At night they switch to repair mode, and that is when MaculaPM® goes to work.*

  1. 01Daytime

    Light & stress

    During the day, the eye is exposed to light and environmental stress.

  2. 02Nighttime

    Maintenance & renewal

    At night, it shifts into a period of maintenance and renewal.

  3. 03The RPE layer

    Pigment biology

    The retinal pigment epithelium continues to process photoreceptor material and maintain cellular balance.

Shop MaculaPM®

One capsule at bedtime. See you in the morning.

Healthy vision depends on more than antioxidants

A more complete view

  1. Signaling

    L-DOPA & retinal signaling

    L-DOPA is naturally occurring in the eye and involved in retinal signaling pathways through the GPR143 receptor in the RPE.*

    Learn more : L-DOPA & retinal signaling
  2. Timing

    Melatonin & circadian rhythm

    Melatonin regulates circadian rhythm and shifts the eye toward maintenance and renewal at night.*

    Learn more : Melatonin & circadian rhythm
  3. Nutrition

    Supporting nutrients

    Lutein, zeaxanthin, and antioxidant vitamins C and E help support normal eye structure and function.*

    Learn more : Supporting nutrients

The formula

What makes the formula different

  1. L-DOPA and the GPR143 receptor

    L-DOPA is the only known endogenous ligand for GPR143, a receptor expressed in the retinal pigment epithelium. MaculaPM® is formulated around this signaling pathway, which standard eye supplements do not address.*

    What's inside : L-DOPA and the GPR143 receptor
  2. Formulated for nighttime biology

    The eye performs its most important maintenance and renewal processes at night. MaculaPM® is designed as a once-nightly formula to align with this circadian cycle, not as a general daily supplement.*

    Why at night : Formulated for nighttime biology
  3. University of Arizona research lineage

    Decades of research in ophthalmology, retinal biology and macular health from the University of Arizona. Licensed through Tech Launch Arizona. Backed by US patents 11,969,401 and 9,173,862.*

    Our patented formula : University of Arizona research lineage

Medical & scientific team

Meet the researchers behind MaculaPM®

Developed by eye doctors and scientists from the University of Arizona, not a marketing department.

  • Robert W. Snyder, MD, PhD

    Robert W. Snyder, MD, PhD

    Chief Clinical Officer

    Ophthalmologist and surgeon with over 40 years of clinical experience. Former Chairman of Ophthalmology at the University of Arizona.

    Read bio : Robert W. Snyder, MD, PhD
  • Murray H. Brilliant, PhD

    Murray H. Brilliant, PhD

    VP Research

    Professor of Ophthalmology at the University of Arizona. 40 years in genetic research. Led the research on L-DOPA's role in the eye.

    Read bio : Murray H. Brilliant, PhD
  • Brian McKay, PhD

    Brian McKay, PhD

    Lead Researcher

    University of Arizona ophthalmology researcher whose work helped establish L-DOPA as the natural ligand for GPR143.

    Read bio : Brian McKay, PhD
  • John A. Martens

    John A. Martens

    Formulation Scientist

    Chemical engineer and chemist. 35 years as a corporate scientist at 3M, bringing rare formulation rigor to every capsule.

    Read bio : John A. Martens
  • Retinal signaling with natural L-DOPA
  • Circadian timing with melatonin
  • Supports nightly cellular maintenance
  • Lutein, zeaxanthin, vitamins C & E

Why MaculaPM® is different

More than an antioxidant formula

Unlike traditional antioxidant-only eye supplements, MaculaPM® takes a broader approach: L-DOPA, a natural signaling molecule for eye health through the GPR143 receptor, and melatonin, which supports circadian timing.*

Choose a purchase option

Secure checkout. Subscriptions renew every 60 days at the discounted price until you cancel.

Our story

Why MaculaPM® exists

Most eye supplements stop at antioxidants. The science has moved forward.

MaculaPM® was created to reflect what researchers now understand about how the eye actually works, including the role of retinal signaling, pigment biology, and the eye's relationship to circadian rhythm.

Customer reviews

What customers are saying

Real reviews from verified MaculaPM® customers.

  • “I appreciate that MaculaPM was designed around how the eye actually functions at night. Taking it before bed fits naturally into my routine and I never forget.”

    Vincent A.Verified buyer

  • “After years of trying different options, MaculaPM is the one I understand and trust the most. The nighttime formulation and the L-DOPA plus melatonin approach are unique.”

    Beverly S.Verified buyer

2 minutes

Is MaculaPM® right for you?

Answer a few simple questions about your eyes and routine, and we will show you where MaculaPM® fits.

MaculaPM® supports, and does not replace, regular care from your eye doctor.