Research & References

Mining retrospective data for virtual prospective drug repurposing: L-DOPA and age-related macular degeneration

Brilliant MH, Vaziri K, Connor TB Jr, et al. — Am J Med. 2016;129(3):292–8

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Levodopa positively affects neovascular age-related macular degeneration

Figueroa AG, Boyd BM, Christensen CA, et al. — Am J Med. 2021;134(1):122–128.e3

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L-DOPA is an endogenous ligand for OA1

Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS — PLoS Biol. 2008;6(9):e236

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PEDF and VEGF-A output from human retinal pigment epithelial cells grown on novel microcarriers

Falk T, Congrove NR, Zhang S, McCourt AD, Sherman SJ, McKay BS — J Biomed Biotechnol. 2012;2012:278932

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Melatonin and risk of age-related macular degeneration

Jeong H, Shaia JK, Markle JC, Talcott KE, Singh RP — JAMA Ophthalmol. 2024;142(7):648

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Effects of melatonin in age-related macular degeneration

Yi C, Pan X, Yan H, Guo M, Pierpaoli W — Ann N Y Acad Sci. 2005;1057:384–392

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Melatonin protects human retinal pigment epithelial (RPE) cells against oxidative stress

Liang FQ, Green L, Wang C, Alssadi R, Godley BF — Exp Eye Res. 2004;78(6):1069–75

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Protective effect of melatonin against oxidative stress-induced apoptosis and enhanced autophagy in human retinal pigment epithelium cells

Chang CC, Huang TY, Chen HY, et al. — Oxid Med Cell Longev. 2018;2018:9015765

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Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the AREDS2 randomized clinical trial

AREDS2 Research Group; Chew EY, Clemons TE, et al. — JAMA. 2013;309(19):2005–15

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Secondary analyses of the effects of lutein/zeaxanthin on AMD progression: AREDS2 report no. 3

Chew EY, Clemons TE, SanGiovanni JP, et al. — JAMA Ophthalmol. 2014;132(2):142–9

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Lutein, zeaxanthin and meso-zeaxanthin supplementation associated with macular pigment optical density — meta-analysis across 20 RCTs

Ma L, Liu R, Du JH, et al. — Nutrients. 2016;8(7):426

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A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for AMD: AREDS report no. 8

AREDS Research Group — Arch Ophthalmol. 2001;119(10):1417–36

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Long-term effects of vitamins C and E, beta-carotene, and zinc on age-related macular degeneration: AREDS report no. 35

Chew EY, Clemons TE, Agrón E, et al. — Ophthalmology. 2013;120(8):1604–11

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Role of oxidative stress in retinal disease and the early intervention strategies: a comprehensive review

Wang J, Li M, Geng Z, et al. — Oxid Med Cell Longev. 2022;2022:7836828

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