Learn how MaculaPM® Works
Research from the University of Arizona
Your eyes do their most important work while you sleep.
Every night, your retina renews the cells you see with. After 60, two natural compounds that support this work start to decline. MaculaPM® is the nightly eye supplement built around that discovery, developed by University of Arizona eye researchers.*
- Supports the retina's natural overnight renewal*
- Formulated around the GPR143 retinal signaling pathway*
- Plus lutein, zeaxanthin and antioxidant vitamins C & E*
- One capsule at bedtime. That's it.
From $0.82 a night with Subscribe & Save · 60-day money-back guarantee
- University-researchedLicensed through Tech Launch Arizona
- Two US patents11,969,401 · 9,173,862
- Ophthalmologist-ledFormer Chairman of Ophthalmology, U of A
- Made in the USA60 capsules · 60-night supply
Why it matters after 50
Your eyes' overnight maintenance slows down with age.
Behind your retina sits a thin layer of cells called the retinal pigment epithelium (RPE). Every night, it recycles and maintains the light-sensing cells you see with.
That work depends on natural signals, including L-DOPA, made by the eye's own pigment cells, and melatonin, your body's nighttime hormone. Both decline naturally as we age.
- ~30 light-sensing cells supported by each RPE cell, every night
- 60+ the age when the natural decline in L-DOPA typically accelerates
- 2 nighttime compounds that decline with age, both in every MaculaPM® capsule
MaculaPM® is designed to provide dietary support for these pathways during the years when your eye's own production may be diminished.*
More than antioxidants
Most eye vitamins are still built on a 1990s formula. The science has moved on.
Carotenoids and antioxidants matter, which is why MaculaPM® includes them. But standard formulas stop there. MaculaPM® adds support for the retina's own nighttime signaling.*
Already take an eye vitamin? MaculaPM® is formulated to be taken alongside other eye supplements and a daily multivitamin. If you take prescription medication, check with your doctor first.
How it works
One capsule, timed to your eye's overnight renewal.
Taken at bedtime, MaculaPM® delivers its nutrients as your retina shifts from daytime seeing to nighttime maintenance.*
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01Bedtime
Melatonin sets the clock
Melatonin is your body's natural nighttime signal. It aligns the formula with the eye's overnight maintenance cycle.*
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02Overnight
L-DOPA activates GPR143
L-DOPA is the only known natural activator of GPR143, a receptor on the RPE cells that look after your photoreceptors. MaculaPM® supplies it from Mucuna pruriens seed extract.*
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03While you sleep
The RPE does its nightly work
RPE cells process and recycle photoreceptor material overnight. MaculaPM® supports the signaling behind this routine maintenance.*
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04All day
Built-in daytime defense
Lutein and zeaxanthin concentrate in the macula and help filter high-energy blue light. Vitamins C and E add antioxidant support.*
Each RPE cell supports approximately 30 photoreceptors, recycling worn material from them every single night.
The discovery
Built on decades of university research.
MaculaPM® grew out of research at the University of Arizona. Eye scientists there have spent years studying how L-DOPA functions in the retina, drawing on large patient populations that included tens of millions of medical records.
The research team's work has received support from the NIH and the BrightFocus Foundation.
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2008
A natural key is identified
Dr. Brian McKay's University of Arizona lab identifies L-DOPA as the natural ligand for the GPR143 receptor in the retina (PLoS Biology).
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2016
Large-scale data research
Dr. Murray Brilliant's team publishes an analysis of retrospective patient data on L-DOPA and eye health in The American Journal of Medicine.
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Patented
Two US patents
The formulation is protected by US patents 11,969,401 and 9,173,862 and licensed through Tech Launch Arizona.
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2021–2026
A growing body of research
Peer-reviewed studies in journals including Ophthalmology Retina, JAMA Ophthalmology and Investigative Ophthalmology & Visual Science continue to examine L-DOPA and melatonin in retinal biology.
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Today
MaculaPM®
The research becomes a nightly dietary supplement, developed with the scientists behind it.*
The team
Developed by eye scientists, not a marketing department.
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“The eye does not age in isolation. It is a dynamic biological system that depends on daily maintenance, circadian timing, and molecular signaling. MaculaPM® reflects a deeper understanding of that system.”
Robert W. Snyder, MD, PhD
Chief Clinical Officer
Ophthalmologist and surgeon with over 40 years of clinical experience. Former Chairman of Ophthalmology at the University of Arizona.
Read bio : Robert W. Snyder, MD, PhD -
“L-DOPA is not just a signaling molecule. It sits at a unique crossroads of retinal biology that no other eye supplement has addressed.”
Murray H. Brilliant, PhD
VP Research
Professor of Ophthalmology at the University of Arizona. 40 years in genetic research. Led the research on L-DOPA's role in the eye.
Read bio : Murray H. Brilliant, PhD -
Brian McKay, PhD
Lead Researcher
University of Arizona ophthalmology researcher whose work helped establish L-DOPA as the natural ligand for GPR143.
Read bio : Brian McKay, PhD -
John A. Martens
Formulation Scientist
Chemical engineer and chemist. 35 years as a corporate scientist at 3M, bringing rare formulation rigor to every capsule.
Read bio : John A. Martens
What's inside
Six ingredients. Clear doses. One capsule.
Every amount below matches the Supplement Facts label. Nothing is hidden in a proprietary blend.
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Patented approach
L-DOPA
100 mgFrom 200 mg Mucuna pruriens seed extract
Supports retinal signaling through the GPR143 receptor in the retinal pigment epithelium.*
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Melatonin
5 mgYour body's nighttime hormone. Aligns the formula with the eye's overnight maintenance and renewal cycle.*
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Lutein
5 mgFrom marigold flower (Tagetes erecta)
Concentrates in the macula to help filter high-energy blue light and support macular pigment.*
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Zeaxanthin
2 mgFrom marigold flower (Tagetes erecta)
Works alongside lutein in the center of the macula to support central vision.*
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Vitamin C
100 mgAs ascorbic acid
An antioxidant that helps support the body's natural defenses against oxidative stress in retinal cells.*
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Vitamin E
35 mgAs d-alpha tocopheryl acid succinate
Supports antioxidant defense in photoreceptor cell membranes.*
Other ingredients: microcrystalline cellulose, hydroxypropyl methylcellulose, maltodextrin, sucrose, plant gelatin, vegetable magnesium stearate, modified food starch, starch, silica. Manufactured in the USA.
Customer reviews
What customers are saying
- One capsule at bedtime
- 60 capsules, 60 nights
- Two US patents
- Made in the USA
Start tonight
Choose your MaculaPM® plan
One capsule at bedtime. Each bottle is a 60-night supply.
60-day money-back guarantee
Secure checkout. Subscriptions renew every 60 days at the discounted price until you cancel.
Our promise
Try it for 60 nights. If it's not for you, get your money back.
We stand behind the science. If you're not satisfied for any reason, email info@aginghs.com within 60 days of your first order and we'll refund your purchase.
Can I take MaculaPM® with my current eye vitamin?
Yes. MaculaPM® is formulated to be taken alongside other eye supplements, including AREDS-style formulas, and a daily multivitamin. It adds nighttime support that standard formulas don't include.*
Why do I take it at night?
Your retina does most of its maintenance and renewal while you sleep. MaculaPM® is timed to that cycle, and it contains melatonin, your body's natural nighttime signal. Take one capsule before bed with a glass of water.
What is L-DOPA? Is it a drug?
L-DOPA is a naturally occurring compound. Your body makes it, including the pigment cells in your eye. In MaculaPM® it comes from the seed of Mucuna pruriens, a tropical legume, at 100 mg per capsule. MaculaPM® is a dietary supplement, not a drug.
Are there side effects or interactions?
MaculaPM® is generally well tolerated. Because it contains melatonin, some people feel drowsy, which is why it is taken at bedtime. Melatonin may interact with sedative medications, and L-DOPA may interact with some prescription medications. If you take other medications, are pregnant or nursing, or have a medical condition, talk with your doctor before use.
How long should I take it?
MaculaPM® is designed as a nightly habit. Like any nutritional support, it's meant to be taken consistently over time. That's why most customers choose Subscribe & Save, so they never run out.
How does Subscribe & Save work?
You save 15% on every bottle and a new 60-night supply ships every 60 days. You can skip a delivery or cancel anytime from your account.
What if it's not for me?
You're covered by our 60-day money-back guarantee. Email info@aginghs.com within 60 days of your first order and we'll refund your purchase.
Is this a replacement for seeing my eye doctor?
No. MaculaPM® is a dietary supplement intended to support macular and retinal health.* It is not a substitute for professional eye care, regular exams, or any treatment your provider recommends.
Selected research(8)
- Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS. L-DOPA is an endogenous ligand for OA1. PLoS Biol. 2008;6(9):e236.
- Brilliant MH, Vaziri K, Connor TB Jr, et al. Am J Med. 2016;129(3):292–8.
- Falk T, Congrove NR, Zhang S, McCourt AD, Sherman SJ, McKay BS. PEDF and VEGF-A output from human retinal pigment epithelial cells grown on novel microcarriers. J Biomed Biotechnol. 2012.
- Hyman MJ, et al. Ophthalmol Retina. 2023;7(9):745–752.
- Murati F, et al. Levodopa in retinal disease: dopamine pathways, neuroprotective mechanisms, and clinical evidence. Surv Ophthalmol. 2026.
- Jeong H, et al. JAMA Ophthalmol. 2024;142(7):648.
- AREDS2 Research Group; Chew EY, et al. JAMA. 2013;309(19):2005–15.
- Ma L, et al. Nutrients. 2016.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
MaculaPM® is a dietary supplement, not a drug. Research cited refers to individual ingredients and pathways, not to MaculaPM® as a finished product. Individual results may vary. Consult your physician before use if you are pregnant, nursing, taking medication, or have a medical condition.