Dr. Brian McKay

Chronology of Employment :

Kohart Inc., Assistant Manager, 1981-1987

Medical College of Wisconsin, Laboratory Technologist, 1987-1989

Duke University, Research Assistant Professor, 1997-2002

University of Arizona, Assistant Professor, 2002-2008

University of Arizona, Associate Professor, 2008-2018

University of Arizona, Professor, 2018-present

• The Scripps Research Institute Award for Excellence in Vascular Biology, 1996
• Research to Prevent Blindness Career Development Award, 1998
• Community Award “Outstanding Medical Researcher” Tucson Media Association, 2017

Duke University:  2002-2002, Laboratory Instructor for Introduction to Cell Biology.

Duke University:  2000-2002, Laboratory Instructor for Microanatomy.

University of Arizona:  2003, Facilitator for Problem Based Learning.

University of Arizona:  2003, Laboratory Instructor for Histology.

University of Arizona:  2003, Facilitator for Problem Based Learning.

University of Arizona:  2003, Laboratory Instructor for Histology.

University of Arizona:  2005, Lecturer in Science Writing

University of Arizona:  2006, Lecturer in Medical Neuroscience

University of Arizona:  2006, Facilitator in Medical Neuroscience

University of Arizona:  2007, Facilitator in Medical Neuroscience

University of Arizona:  2008, Lecturer in Neuropharmacology

University of Arizona:  2008, Facilitator in Medical Neuroscience

University of Arizona:  2008, Lecturer in Medical Neuroscience (Phoenix Campus)

University of Arizona:  2004-2008, Faculty participant, Current Research in Ophthalmology and Vision Science Journal Club

University of Arizona:  2008, Course Director, Vision Science Colloquium

University of Arizona:  2009, Facilitator in Medical Neuroscience

University of Arizona:  2009, Course Director, Vision Science Colloquium

University of Arizona:  2009, Facilitator in Cardio, Pulmonary, Renal Medical Block

University of Arizona:  2010, Facilitator in Medical Neuroscience

University of Arizona:  2010, Facilitator in Cardio, Pulmonary, Renal Medical Block

University of Arizona:  2010, Course Director, Vision Science Colloquium

University of Arizona:  2010, Lecturer, Medical Pharmacology – Ocular Pharmacology I&II

University of Arizona:  2011, Facilitator in Medical Neuroscience

University of Arizona:  2011, Facilitator in Cardio, Pulmonary, Renal Medical Block

University of Arizona:  2011, Course Director, Vision Science Colloquium

University of Arizona:  2011, Lecturer, Medical Pharmacology – Ocular Pharmacology I&II

University of Arizona:  2012, Facilitator in Cardio, Pulmonary, Renal Medical Block

University of Arizona:  2012, Course Director, Vision Science Colloquium

University of Arizona:  2012, Facilitator in Medical Neuroscience

University of Arizona:  2012, Lecturer in Medical Neuroscience

University of Arizona:  2012, Laboratory instructor in Medical Neuroscience

University of Arizona:  2013. Facilitator in Cardio, Pulmonary, Renal Medical Block

University of Arizona:  2013, Facilitator in Medical Neuroscience

University of Arizona:  2014, Facilitator in Cardio, Pulmonary, Renal Medical Block

University of Arizona:  2014, Facilitator in Medical Neuroscience

University of Arizona:  2015, Facilitator in Cardio, Pulmonary, Renal Medical Block

University of Arizona:  2015, Facilitator in Integrated Medicine.

University of Arizona:  2015, Course Director, Vision Science Colloquium 

University of Arizona:  2016, Facilitator in Integrated Medicine. (Fall semester)

University of Arizona:  2016, Course Director, Vision Science Colloquium 

University of Arizona:  2017, Facilitator in Integrated Medicine. (Spring semester)

University of Arizona:  2017, Course Director, Vision Science Colloquium 

University of Arizona:  2017, Facilitator in Integrated Medicine. (Fall semester)

University of Arizona:  2018, Course Director, Vision Science Colloquium 

University of Arizona:  2018, Facilitator in Integrated Medicine. (Spring semester)

University of Arizona:  2018, Lecture, Current Thoughts on AMD.

University of Arizona:  2018, Facilitator in Integrated Medicine. (Fall semester)

University of Arizona:  2019, Course Director, Vision Science Colloquium 

University of Arizona:  2019, Facilitator in Integrated Medicine. (Spring semester)

University of Arizona:  2020, Course Director, Vision Science Colloquium

University of Arizona:  2021, Course Director, Vision Science Colloquium

University of Arizona:  2022, Course Director, Vision Science Colloquium

University of Arizona:  2023, Course Director, Vision Science Colloquium

University of Arizona:  2024, Course Director, Vision Science Colloquium

Students:

 

1. Thesis Committee for Katherine M. Hardy. Gerontology Department, University of Arizona.  Graduation: 2003

Ph.D. Dissertation Committee for Laura E. Lamb, Department of Chemistry. Duke University. Graduation: 2004.

Ph.D.  Dissertation Committee for Tyson R. Kinnic, Physiological Science Training Program, University of Arizona.  Graduation: 2006.

Undergraduate Research:  Carrie Whiting, BS. 2003-2006.  Department of Biochemistry, Awarded the Annual Outstanding Undergraduate Researcher in 2006.

Ph.D.  Dissertation Committee for Kaspar Russ, Department of Neuroscience, University of British Columbia, Vancouver, Canada. 2013

Medical Student Teaching, University of Arizona, Ryan Teeple, graduated 2005-2008, Awarded Medical Student Research Scientist Best in Class 2008.

NIH High School Student Research Program, University of Arizona:

Moriah Martinez, Summer 2014.

Angela Weger, Summer 2014

Undergraduate Research: Christina Locke 2012-2015

Masters student Biomedical Engineering: Kyle Patrick Hadinger 2015 

Medical Student Research: Trent Bowen 2012-2015 MSTP program.

Awarded MSTP Student Research Best in Class, 2015

Master Student Pharmacology program, Doraid Sadideen, graduated with his MS spring 2016.

Master Student Thesis Committee, Cell and Molecular Medicine, Amanda Chung 2016-2018 )

Honors Research Program Summer 2016-2018. Anna G. Figueroa. 

Honors and Awards (Anna):

Best Honors Thesis Elevator Pitch award, University of Arizona Honors College, Spring 2018.

Outstanding Honors Transfer Graduate, University of Arizona, Spring 2018      

LSMCE conference awarded by Indiana University; Fourth Place Poster, Fall 2017

Travel Award for Role Models Conference, Washington, DC, Fall 2017

Travel Award for LSMCE Conference, Fall 2017

University of Arizona Health Sciences FRONTERA Scholar,  Summer 2017

12th Annual WAESO Conference: Third Place Poster in Life Sciences, March 2017

Travel Award for Nathan Shock Symposium, University of Texas Health Science Center at San Antonio, October 2016

Undergraduate Research Opportunity Consortium Scholar, Summer 2016

Phi Theta Kappa Scholarship, 2015 - 2017  

 

Rory Edward Morrison-Colvin, Senior, Biomedical Engineering Fall 2017-spring 2019.

Sara Ann Sillik, Honors Research Program, Undergraduate Fall 2016-Spring 2020.

Mariel Piotrowicz, Medical Student Research Program, Fall 2016-Spring 2020.

Brandon Walter Good. Undergraduate Research Program. Summer 2020.

Dorothy Tung. Honors Research Program (UBRP), Summer 2020-2022.

Leslie Dominguez. Cell and Molecular Biology, master’s thesis committee, 2021-2022. 

Tawanda Zvavamwe, Undergraduate Researcher, 2022-2023.

Remi Bliss, UBRP Honors Student. 2022-present.

Induvahi Veernala, BDS, Mtech, Ph.D. 2023-2024

 

Current:

Serena Rae Yanex, Undergraduate Researcher, 2024-Present

Parichehr Ghahari, MD. Postdoctorsal Fellow, 2024-Present

Lane Vaquez Luna, Undergraduate Researcher, 2025-Present

Outreach:  

Local/state

12/02 “Transplantation of RPE to Treat Age-Related Macular Dystrophy” Green Valley Community Center

1/03 “To RPE or Not to RPE:  Transplantation is the Question” Diseases of the Aging Eye Community Symposia  

1/03 “RPE Mythology” Science of Eye Disease

1/04 “RPE Transplantation for treating diseases of aging” Scottsdale Community Center.

4/06 “AMD Research: Potential and Promise” Tucson Association for the Blind, Tucson, AZ

4/06  “Transplantation of RPE cells for Degenerative Diseases”  Stem Cell Conference, Tucson, AZ.

10/06 “OA1 function in Pigmentation and Disease”,  The Sunstone Healing Center, Tucson AZ.

12/06 “Cell Based Therapy for Parkinson’s Disease” The Parkinson’s Disease Research Program, Duvall Auditorium,. Tucson, AZ.

5/07 “RPE Transplantation for Parkinson’s Disease” Frontiers in Medicine, Kewitt Auditorium, Tucson AZ.

2007-2012: Medical Research Building Neuroscience Program, Bi-monthly Parkinson’s Tours and lunches for the community.

3/08 “Cell Based Therapies for the Treatment of Parkinson’s Disease” Keynote Address. Power Over Parkinson’s Tucson Conference, Marriott Starr Pass Resort.

4/08 “RPE Transplantation for Parkinson’s Disease” Sierra Vista Parkinson’s Disease Association, SierraVista, AZ.

5/08 “How RPE Functions to Treat Parkinson’s Disease” Frontiers in Medicine,  Kewitt Auditorium, Tucson, AZ.

             2/13 “New ideas and methods to treat and prevent AMD” University of Michigan Alumni Association.  Skyline Country Club, Tucson, AZ.

             2/15 “Ocular pharmacology for the most eye diseases” University of Arizona Optometry Club. Science and Engineering Library. 

             2/16 “New Hope to Stop the AMD Epidemic” Tucson Breakfast Lion’s Club, Tucson, AZ.

             2/16 “AMD and Glaucoma – Two Sides of the Same Coin?” University of Arizona Center on Aging, Tucson, AZ

             3/16 “Recent Advances in AMD: We can prevent the disease” Friends of Yuma Society, Yuma Arizona.

             9/16 “Can We Stop AMD” Oro Valley Vision support group, Oro Valley, AZ

             3/17 “New Hope to Stop Blindness” Voyager Park Lecture Series, Tucson, AZ

 9/17 Community Award “Outstanding Medical Researcher” Tucson Media Association, 2017

 4/19 “We can Prevent AMD” Lion’s Club Healthfair. Tucson, AZ. The Radisson Inn and Suites. 

 7/19 “We can Fix Albinism and Prevent AMD” Tucson School for the Blind. Christ Presbyterian Church, Tucson, AZ.

 9/19 “Team Progress on AMD -An Update” LIONS SPECIAL EVENT

Visitor’s Day Series #1Breakfast with Dr. Brian S. McKay. The Sabbar Shrine Center. Tucson, Arizona.

 11/19 “We Can Treat AMD, Team Update on AMD, Lets Finish the Job!” Greater Phoenix Lions, 5 chapters together. Embassy Suites, Tempe, AZ.

 8/20 “We Are Fixing AMD: Results from the Prospective Clinical Trial with L-DOPA” Tucson Society For the Blind. Moved on Line via Zoom due to Pandemic.

 3/21 “Team Update- The Cure for AMD is Coming Through Tucson” Tucson Breakfast Lions Club and Lions Club International via Zoom.

 4/22 “A New Mechanism for L-DOPA Treatment of AMD” Tucson Breakfast Lions Club. Tucson, AZ and Lions Club International vis Zoom.

11/22 “Thank You for the Support” McKay Lab tour for AZ State Lion’s Members.

Seminars by Drs. Holmes and McKay MRB conference room. Tours MRB230.

 5/23 “20 Years of Progress on AMD” McKay Lab tour and seminar. Tucson Breakfast Lions Club, MRB230.

 5/23 “We can Treat and Prevent AMD” McKay lab Tour and seminars by Drs. Holmes and McKay. Rebekahs and Odd Fellows groups MRB230.

8/24 “Progress toward stopping blindness” McKay lab tour. Marana community members, MRB230

1/25 “Glaucoma Ideas” McKay lab tour. Tucson community members, MRB230.

 

Radio:
12/02 KZAZ ‘Star of the Day’ discussing the use of cultured cells to treat AMD and Parkinson’s Disease.
11/15 KQTH 104.1 “L-DOPA may Prevent AMD”. Phoenix, AZ

Internet:
November 15, 201512: VIDEO: Researchers look at effect of L-DOPA on timing of AMD onset. News release American Academy of Ophthalmology annual meeting.
12/15 BrightFocus Chat: December 21. “L-DOPA may Prevent AMD”. Live discussion with a call in audience.
7/17 https://www.facebook.com/kvoa4/posts/1606386226060715
1/23 Interview with Experts: “We can treat and prevent AMD.” https://www.youtube.com/watch?v=xP_yfA6ZjL0

Television:
12/02 KVOA News at 6&10pm discussing the laboratory breakthroughs to treat AMD.
2/03 KVOA “One on One” Discussion of how laboratory research and recent breakthroughs may relate to AMD and Parkinson’s Disease treatments.
2/25/07: Fox News: In Focus. McKay, Cell based therapies for Parkinson’s Disease
3/11/07: KTTU: In Focus with Bob Lee: Parkinson’s Disease.
1/31/13: KGUN9 News: 'Eyeball Express' gets vision research rolling
11/10/15: KVOA4 News: “Prevention of AMD with L-DOPA” http://www.kvoa.com/story/30486589/ua-led-study-reveals-degenerative-eye-disease-prevention-possible
7/10/17: KVOA News “UofA researchers working to prevent the number one cause of blindness”
http://www.kvoa.com/clip/13462543/u-of-a-researchers-working-to-prevent-the-number-one-cause-of-blindness-in-people-over-55
7/15/17: KVOA News: ‘UA leads way to Blindness’
http://www.kvoa.com/story/35805357/ua-leads-way-to-cure-the-1-cause-of-blindness-in-the- world.
8/17. Ivanhoe Media group, include news in 55 cities (large market only), radio spot, and internet blog, and video post.

Press Releases and Articles related to my AMD and L-DOPA discovery:

Impact: A google search of “AMD and L-DOPA” returns over two thousand stories and news releases discussing my retrospective study of AMD incidence in those taking L-DOPA. These stories are in many different languages, indicating the immediate world-wide impact of my work.

Examples:
https://uanews.arizona.edu/sites/default/files/FriendsOfUA_Dec2015.pdf?utm_source=Friends+of+University+of+Arizona&utm_campaign=9f3b4ff5f0-2015_December_Friends_of_UA12_16_2015&utm_medium=email&utm_term=0_5d46115f44-9f3b4ff5f0-241547885

Additionally, the Flinn Foundation mentioned the research in their November newsletter and the UA Now newsletter that reaches 120,000 readers mentions it at https://uanews.arizona.edu/node/61669.

Below are some additional clips. (The news release also went on EurekAlert!)

12/10/2015
Researchers seek path to prevent macular degeneration (Dr. Brian S. McKay, associate professor at the University of Arizona College of Medicine -Tucson)
US News & World Report
Yahoo! News

11/19/2015
Your eyes on dope: Why dopamine could be the solution for macular degeneration (Brian McKay, PhD, associate professor, Department of Ophthalmology and Vision Science, University of Arizona)
Arizona Daily Wildcat

11/16/2015
UA Study Finds Macular Degeneration Can Be Prevented (Brian McKay, PhD, associate professor, Department of Ophthalmology and Vision Science,
University of Arizona)
Arizona Public Media
Inventor Spot
KPHO Phoenix
KTVK-TV

11/13/2015
Parkinson’s Drug Shows Promise Against Macular Degeneration (Brian McKay, PhD, associate professor, Department of Ophthalmology and Vision Science,
University of Arizona)
Drugs.com
MedicineNet.com
NZHealthTec.com
The Health Cast
Fox-Carolina

11/12/2015
UA scientist led research on macular degeneration (Dr. Brian McKay, associate professor of ophthalmology and vision science and cellular and molecular medicine at the University of Arizona College of Medicine)
Arizona Daily Star
Health Medicine Network
NZ Health Tec
Science Codex
Science Daily
TulsaCW.com
PressReleasePoint
Rocket News
ScienceNewsline
Waukesha Now
Yahoo! Finance

11/10/2015
Macular degeneration may be treatable with Parkinson's drug (Brian McKay, PhD, associate professor, Department of Ophthalmology and Vision Science, University of Arizona)
HealthNewsDigest.com
Examiner.com
Business Standard
UPI.com
Medical News Today
Bel Marra Health
EurekAlert (press release)

New study: Leading cause of blindness could be prevented or delayed
Yahoo!, 11/9/15
UPI, 11/9/15
Health Medicine Network, 11/9/15
A drug used to treat Parkinson's and related diseases may be able to delay or prevent macular degeneration, the most common form of blindness among older Americans. The findings, published in the American Journal of Medicine, are a groundbreaking effort in the fight against age-related macular degeneration, or AMD, which affects as many as 11 million Americans. "Rather than looking at what might cause AMD, we instead wondered why certain people are protected from AMD. This approach had never been done before," says senior author Brian McKay of the UA.
Newspaper. 11/3/19
Arizona Daily Wildcat “Parkinson’s Drug May Treat Macular Degeneration” Wildcat Country, 2020 p 35.

1. Jaffe, G. J., Green, G. D. J., McKay, B. S., Hartz, A., and Williams, G. A. (1988). Intravitreal Clearance of Tissue Plasminogen-Activator in the Rabbit. Archives of Ophthalmology 106, 969-972.
*2. Burke, J. M., McKay, B. S., and Jaffe, G. J. (1991). Retinal-Pigment Epithelial-Cells of the Posterior Pole Have Fewer Na/K Adenosine-Triphosphatase Pumps Than Peripheral Cells. Investigative Ophthalmology & Visual Science 32, 2042-2046.
*3. Arrindell, E. L., McKay, B. S., Jaffe, G. J., and Burke, J. M. (1992). Modulation of Potassium-Transport in Cultured Retinal-Pigment Epithelium and Retinal Glial-Cells by Serum and Epidermal Growth-Factor. Experimental Cell Research 203, 192-197.
*4. Murray, T. G., Jaffe, G. J., McKay, B. S., Han, D. P., Burke, J. M., and Abrams, G. W. (1992). Collagen shield delivery of tissue plasminogen activator: functional and pharmacokinetic studies of anterior segment delivery. Refract Corneal Surg 8, 44-8; discussion 48-53.
*5. Burke, J. M., and McKay, B. S. (1993). In-Vitro Aging of Bovine and Human Retinal-Pigment Epithelium - Number and Activity of the Na/K Atpase Pump. Experimental Eye Research 57, 51-57.
*6. Suson, J. D., Nash, R. W., McKay, B. S., and Burke, J. M. (1993). Regional and Sodium-Dependent Variation in Atp and Sodium-Pump Number in RPE. Investigative Ophthalmology & Visual Science 34, 872-872.
*7. McKay, B. S., and Burke, J. M. (1994). Separation of Phenotypically Distinct Subpopulations of Cultured Human Retinal-Pigment Epithelial-Cells. Experimental Cell Research 213, 85-92.
*8. Nash, R. W., McKay, B. S., and Burke, J. M. (1994). The Response of Cultured Human Retinal-Pigment Epithelium to Hypoxia - a Comparison to Other Cell-Types. Investigative Ophthalmology & Visual Science 35, 2850-2856.
9. Burke, J. M., Skumatz, C. M. B., Irving, P. E., and McKay, B. S. (1996). Phenotypic heterogeneity of retinal pigment epithelial cells in vitro and in situ. Experimental Eye Research 62, 63-73.
10. McKay, B. S., Annis, D. S., Honda, S., Christie, D., and Kunicki, T. J. (1996). Molecular requirements for assembly and function of a minimized human integrin alphaIIbbeta3. Journal of Biological Chemistry 271, 30544-7.
11. McKay, B. S., and Burke, J. M. (1997). Cell association increases RPE outgrowth from primary explant. Current Eye Research 16, 891-9.
12. McKay, B. S., Irving, P. E., Skumatz, C. M. B., and Burke, J. M. (1997). Cell-cell adhesion molecules and the development of an epithelial phenotype in cultured human retinal pigment epithelial cells. Experimental Eye Research 65, 661-671.
13. Stamer, W. D., Bok, D., Hu, J., Jaffe, G. J., and McKay, B. S. (2003). Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement. Investigative Ophthalmology & Visual Science 44, 2803-8.
14. Yang, P., McKay, B. S., Allen, J. B., Roberts, W., and Jaffe, G. J. (2003). Effect of Mutant IkB on Cytokine-induced Activation of Nf-kB in Cultured Human RPE Cells. Investigative Ophthalmology & Visual Science 44, 1339-1347.
15. Yang, P., McKay, B. S., Allen, J. B., and Jaffe, G. J. (2004). Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells. Investigative Ophthalmology & Visual Science 45, 2438-2446.
16. Hardy, K. M., Hoffman, E. A., Gonzalez, P., McKay, B. S., and Stamer, W. D. (2005). Extracellular trafficking of myocilin in human trabecular meshwork cells. Journal of Biological Chemistry 280, 28917-28926.
17. Hoffman, E. A., Conley, S. M., Stamer, W. D., and McKay, B. S. (2005). Barriers to productive transfection of trabecular meshwork cells. Molecular Vision 11, 869-875.
18. Conley, S. M., McKay, B. S., Gandolfi, A. J., and Stamer, W. D. (2006). Alterations in human trabecular meshwork cell homeostasis by selenium. Experimental Eye Research 82, 637-47.
19. McLaughlin, P. J., Chen, Q., Horiguchi, M., Starcher, B. C., Stanton, J. B., Broekelmann, T. J., Marmorstein, A. D., McKay, B.S., Mecham, R., Nakamura, T., and Marmorstein, L. Y. (2006). Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice. Mol Cell Biol 26, 1700-9.
20. Rak, D. J., Hardy, K. M., Jaffe, G. J., and McKay, B. S. (2006). Ca++-switch induction of RPE differentiation. Experimental Eye Research 82, 648-56.
21. McKay B. S, Goodman B, Falk T, Sherman S. J. Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson's disease: results from an in vitro model system. Experimental Neurology 2006;201 (1):234-43.
22. Stamer W. D, Perkumas K, Hoffman E. A, Roberts B. C, Epstein D. L, McKay B. S. Coiled-Coil Targeting of Myocilin to Intracellular Membranes. Experimental Eye Research 2006;83 (6):1386-95.Perkumas K, Hoffman EA,
23. Perkumas K, Hoffman E. A, McKay B .S, Allingham R. R, Stamer W. D. Myocilin-Associated Exosomes in Human Ocular Samples Experimental Eye Research 2007;84 (1):209-12.
24. Bakall B, Radu R, Stanton J. B., Burke J.M, McKay B. S., Wadelius C, Mullins R, Stone E, Travis G.H, Marmorstein A.D. Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2). Experimental Eye Research. 2007 Jul:85(1):34-43.
25. Ling Y, Kelly U, Ebright J. N., Malek G, Saloupis P, Rickman D, McKay B. S., Arshavsky V. Y., Bowes – Rickmana C. Oxidative Stress-Induced Expression and Modulation of
Phosphatase of Regenerating Liver-1 (PRL-1) in Mammalian Retina. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2007. Sep;1773(9):1473-82.
26. Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS L-DOPA is an endogenous ligand for OA1. PLoS Biol 2008 6(9): e236.
Voted Faculty of 1000 Must Read. In the top 25% of all research outputs ever scored by Altmetric.

27. McKay, B. S., Miller J. Macular Degeneration. Encyclopedia Britannica. 2008, updated 2014.
28. Falk, T., N.R. Congrove, S.L. Zhang, A.D. McCourt, S.J. Sherman and B.S. McKay PEDF and VEGF-A output from human retinal pigment epithelium cells grown on novel microcarriers. 2012 Journal of Biomedicine and Biotechnology, 2012: 278932.
29. Dismuke, W. M., McKay, B. S., Stamer, W. D. Myocilin, a Component of a Membrane-Associated Protein Complex Driven by a Homologous Q-SNARE Domain. Biochemistry 2012 51 (17):3606-13.
30. McKay, B. S., Congrove, N. R., Johnson, A. A., Dismuke, W. M., Bowen, T.J., Stamer, W. D. A Role for Myocilin in Receptor-Mediated Endocytosis. PLoS ONE 2013. 8(12): e82301. doi:10.1371/journal.pone.0082301
31. Summers, C. G., Connett, J. E., Holleschau, A. M., Anderson, J. L., De Becker, I., McKay, B. S., and Brilliant, M. H. Does levodopa improve vision in albinism? Results of a randomized, controlled clinical trial. Clinical & Experimental Ophthalmology 42, 713-721 (2014).
32. Locke, C. J., Congrove, N. R., Dismuke, W. M., Bowen, T. J., Stamer, W. D., and McKay, B. S. Controlled exosome release from the retinal pigment epithelium in situ. Experimental Eye Research 129. 1-4 (2014).
33. Murray H. Brilliant, Kamyar Vaziri, Thomas B. Connor, Jr., Stephen G. Schwartz, Joseph J. Carroll, Catherine A. McCarty, Steven J. Schrodi, Scott J.Hebbring, Krishna S. Kishor, Harry W. Flynn, Jr, Andrew A. Moshfeghi, Darius M. Moshfeghi, M. Elizabeth Fini, Brian S. McKay. Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration. American Journal of Medicine. 2016 Mar;129(3):292-8.
Altimetric Ranking: “Altmetric has tracked 4,845,947 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.”
34. McKay, B. S. and Schwartz, S. G. Pigmentation and Macular Degeneration: Is There a Role for GPR143? J Ocul Pharmacol Ther. 2016 Jan-Feb;32(1):3-4. doi: 10.1089/jop.2016.29007.bsm. PMID: 26741053
35. McKay BS, Allingham RR, Stamer WD. Is there a final common pathway affected in POAG? Glaucoma Research and Clinical Advances: 2018 to 2020 - Google Books [Internet]. 2nd ed. John R. Samples, Paul A. Knepper, editors. Kugler Publications; 2018. Is there a final common pathway in POAG? Pages 99-110.
36. McKay BS, Lynch RM, Stamer WD. Comment on "Identification of Novel G Protein-Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism" Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4733-4734. doi: 10.1167/iovs.17-22660. PMID:28910826
37. McKay, B.S. “Pigmentation and Vision: Is GPR143 in Control?” J. Neuro Sci Res. 2019:97:77-87. PMID: 29761529
38. Chung AG, Frye JB, Zbesko JC, Constantopoulos E, Hayes M, Figueroa AG, Becktel DA, Antony Day W, Konhilas JP, McKay BS, Nguyen TV, Doyle KP. Liquefaction of the Brain following Stroke Shares a Similar Molecular and Morphological Profile with Atherosclerosis and Mediates Secondary Neurodegeneration in an Osteopontin-Dependent Mechanism. eNeuro. 2018 Nov 8;5(5) PMID: 30417081
39. Nguyen TV, Hayes M, Zbesko JC, Frye JB, Congrove NR, Belichenko NP, McKay BS, Longo FM, Doyle KP. Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia. Acta Neuropathol Commun. 2018 Sep 24;6(1):100. doi: 10.1186/s40478-018-0603-4.
PMID: 30249297
40. Figueroa AG, McKay, BS. GPR143 Signaling and Retinal Degeneration. Adv Exp Med Biol. 2019;1185:15-19. doi: 10.1007/978-3-030-27378-1_3.PMID: 31884582
41. Figueroa AG, McKay BS. A G-Protein Coupled Receptor and Macular Degeneration. Cells. 2020;9(4):E910. Published 2020 Apr 8. doi:10.3390/cells. PMID: 32276449.
42. Figueroa AG, Boyd BM, Christensen CA, Javid CA, McKay BS, Fagan TC, Snyder RW. Levodopa Positively Affects Neovascular Age-related Macular Degeneration. American Journal of Medicine, 2021 Jan;134(1):122-128.e3. PMID: 32628915.
43. Bowers EC, Cavalcante AM, Knox, K, McKay BS, Ramos KS. Extracellular vesicle export of the cancer biomarker LINE-1: Compartmentalization of cargo and reverse transcriptase activity in lung cancer cells and plasma from human subjects. International Journal of Molecular Science 2022 Mar 22;23(7):3461. doi: 10.3390/ijms23073461. PMID: 35408821.
44. Emri E, Cappa O, Kelly C, Kortvely E, SanGiovanni JP, McKay BS, Bergen AA, Simpson DA, Lengyel I. Zinc Supplementation Induced Transcriptional Changes in Primary Human Retinal Pigment Epithelium: A Single-Cell RNA Sequencing Study to Understand Age-Related Macular Degeneration. Cells. 2023 Feb 28;12(5):773. doi: 10.3390/cells12050773. PMID: 36899910; PMCID: PMC10000409.
45. Hyman MJ, Skondra D, Aggarwal N, Moir J, Boucher N, McKay BS, MacCumber MW, Lavine JA. Levodopa is associated with reduced development of neovascular age-related macular degeneration. Ophthalmol Retina. 2023 May 3:S2468-6530(23)00198-7. doi: 10.1016/j.oret.2023.04.014. Epub ahead of print. PMID: 37146684.
46. Tung D, McKay BS. Decoding Race and Age-Related Macular Degeneration: GPR 143 Activity Is the Key. Adv Exp Med Biol. 2023;1415:43-47. doi: 10.1007/978-3-031-27681-1_7.PMID: 37440012
47. Tung D, Congrove NR, Figueroa AG, Bliss RM, Zvavamwe T, Veernala I, McKay BS. An Unexpected Role for GPR143 in Retinal Homeostasis. Submitted.
48. McKay BS, Grabrucker AM, Thompson RB, Chew EY, Lengyel I, Gonzalez-Iglesias H. Zinc in the retina and its involvement in retinal diseases. Progress in Retinal and Eye Research. In Press

Patents

Methods for Treating and Identifying Compounds to Treat Age-Related Macular Degeneration Inventor: McKay, Brian S. and John Martins. Patent: WO/2009/129497. Patent is granted in USA, EU, and Australia.

SYSTEMS AND METHODS FOR CHARACTERIZING AND TREATING DISEASE. Inventors: Kenneth Ramos, Emma Bowers, Patrick Silva, Brian McKay. Application 62/787,444, filed 1/2/19

 

Invited Seminars:
“Myocilin Functions in the Secretory pathway” September 1999, Asheboro, North Carolina. Invited Speaker, Department of Cell Biology, Duke University Medical Center.
“Myocilin: a Molecular Address that Delivers Adhesion Molecules to Nascent Junctions” December 1999, Chapel Hill, North Carolina. Department of Cell Biology, Integrin Special Interest Group. University of North Carolina at Chapel Hill.
“Myocilin is a SNARE Associated Protein” April 2000, San Francisco, CA,. Glaucoma Research Foundation Catalyst Meeting.
“Autologous RPE transplantation for treatment of AMD and Parkinson’s Disease”
Translational Research Seminar 2005, Arizona Board of Reagents.
“Ca++ Switch Induction of RPE Differentiation” May 2005. Association for Research in Vision and Ophthalmology, Ft. Lauderdale, FL Special Interest Group Panel
“Transplantation of RPE cells for disease Stem Cell Conference” April 2006 Stem Cell Conference, Tucson, AZ.
“OA1 function in Pigmentation and Disease” October, 2006. The Sunstone Healing Center, Tucson, AZ.
“RPE Cell Based Therapy for Parkinson’s Disease” 2008. Keynote Address, Annual Meeting of the American Parkinson’s Disease Association, Marriot Starr Pass Resort, Tucson, AZ, March, 2008.
“L-DOPA is the Endogenous Ligand of OA1” Invited Speaker, Annual meeting of the Vision of Children Foundation May 19, 2009, San Diego, Ca.
“L-DOPA is the endogenous Ligand for OA1” Plenary Address, The European Society for Pigment Cell Research. September 23, 2009. Muenster, Germany.
“Pigmentation and Vision: A Connection between the two most common causes of blindness” Invited Speaker, September 5, 2014. Hope for Vision Foundation, Miami, FL.
“Solving the Riddle of Pigmentation and Retinal Degeneration” University of Arizona Center on Aging March 18, 2017 Tucson, AZ.
“New use for an Old Drug”. Department of Neuroscience Grand Rounds, University of Arizona. February 1, 2019.
“We can Fix Albinism and Prevent AMD”. Keynote Speaker. Foundation Fighting Blindness Annual symposia, George Miller Golf Links, May 11, 2019.
“Decoding AMD: Race and Pigmentation”. Amigo Monthly meeting. Ireland (online) Feb 11, 2022.
“GPR143 and the Quest to Cure AMD” Molecular Physiology and Biophysics, University of Iowa, Iowa City. IA. 7/26/23

Symposia
“Molecular Basis of Glaucoma Studied through Myocilin Mutations” August, 2003. Inherited Eye Disease Symposia, Duke University
“Cell Based Therapies for the Treatment of Parkinson’s Disease” March 2008. Keynote Address. Power Over Parkinson’s Tucson Conference 3/08, Marriott Starr Pass Resort.
“Albinism and extracutanous melanin” Session Chair. European Society for Pigment Cell Research. September 23, 2009. Muenster, Germany.
Special interest group symposia “Extracellular Vesicles in the Anterior Segment”. Association for Research in Vision and Ophthalmology. May 2018, Honolulu, HI.
“GPR43 Signaling and Retinal Degeneration”. XVIII International Symposium on Retinal Degeneration (2018) Killarney, Ireland September 2018.
“New Use for an Old Drug, AMD and L-DOPA” Invited Symposia, Association for Research in Vision and Ophthalmology, May 2019, Vancouver, CA
Ocular Pigmentation and Vision Session Moderator, International Society for Eye Research, February 2023.
“GPR143: the Lynch Pin connecting RPE Pigmentation to Vision” Invited Symposia, International Society for Eye Research, February 2023, Gold Coast, Australia.

 

Submitted Presentations (Abstracts)

1. McKay, B. S., and J. M. Burke. 1991. Irradiated Feeder Layers Enhance Primary Outgrowth of RPE. Investigative Ophthalmology & Visual Science 32: 1303-1303.
2. McKay, B. S., and J. M. Burke. 1992. Epithelialization of Human Retinal-Pigment Epithelium (RPE) Invitro. Molecular Biology of the Cell 3: A290-A290.
3. McKay, B. S., J. D. Suson, and J. M. Burke. 1992. Subpopulations of Human RPE Invitro. Investigative Ophthalmology & Visual Science 33: 1204-1204.
4. McKay, B. S., R. L. Sabina, and J. M. Burke. 1993. Amp-Deaminase Expression in Cultured Human Rpe. Investigative Ophthalmology & Visual Science 34: 983-983.
5. Nash, R. W., B. S. McKay, J. D. Suson, and J. M. Burke. 1993. RPE Sensitivity to Hypoxia Invitro. Investigative Ophthalmology & Visual Science 34: 869-869.
6. Suson, J. D., R. W. Nash, B. S. McKay, and J. M. Burke. 1993. Regional and Sodium-Dependent Variation in ATP and Sodium-Pump Number in RPE. Investigative Ophthalmology & Visual Science 34: 872-872.
7. McKay, B. S., S. Honda, D. S. Annis, and T. J. Kunicki. 1995. Molecular Requirements for Species-Restricted Dimerization of Human Integrin Alpha(Iiib) with Beta(3). Blood 86: 2204-2204.
8. McKay, B. S., D. S. Annis, S. Honda, D. Christie, and T. J. Kunicki. 1996. Molecular Requirements for Assembly and Function of a Human Alpha(Iib)Beta(3) Mini-Integrin. Molecular Biology of the Cell 7: 1435-1435.
9. Kunicki, T. J., and B. S. McKay. 1997. Molecular Requirements for Human Integrin Alpha Beta Subunit Association. Blood 90: 1909-1909.
10. McKay, B. S., D. S. Annis, S. Honda, D. J. Christie, and T. J. Kunicki. 1997. Assembly of a Functional Human Alpha(Iib)Beta(3) Minigrin. Thrombosis and Haemostasis: P2744-P2744.
11. Stamer, W. D., B. C. Roberts, D. L. Epstein, and B. S. McKay. 1998. Myocilin Functions in Vesicle Formation and Fusion. Molecular Biology of the Cell 9: 206A-206A.
12. Denny, J. P., G. J. Jaffe, and B. S. McKay. 1999. The Effect of Tamoxifen on Cadherin Expression in Cultured Human Rpe. Investigative Ophthalmology & Visual Science 40: S924-S924.
13. McKay, B. S., B. C. Roberts, and W. D. Stamer. 1999. Myocilin Functions in Cell-Cell Junction Formation. Molecular Biology of the Cell 10: 410A-410A.
14. McKay, B. S., B. C. Roberts, and W. D. Stamer. 2000. Myocilin: A Molecular Address for Nascent Junctions. Investigative Ophthalmology & Visual Science 41: S843-S843.
15. McKay, B. S., W. D. Stamer, and H. P. Erickson. 2000. Myocilin Is a Vamp-Associated Protein. Molecular Biology of the Cell 11: 116A-116A.
16. Stamer, W. D., R. R. Allingham, B. C. Roberts, and B. S. McKay. 2000. Subcellular Localization of Myocilin Mutants. Investigative Ophthalmology & Visual Science 41: S523-S523.
17. McKay, B. S., H. P. Erickson, and W. D. Stamer. 2001. Myocilin: A Vesicle Tether in Retina and Rpe. Investigative Ophthalmology & Visual Science 42: S193-S193.
18. Rickman, C. B., B. S. McKay, T. O. Yarovinsky, and D. W. Rickman. 2001. Analysis of Proteins Encoded by Two Fovea-Associated Candidate Genes for Macular Dystrophies. Investigative Ophthalmology & Visual Science 42: S770-S770.
19. Hoffman, E. A., E. P. Ryan, B. S. McKay, and W. D. Stamer. 2002. Biochemical Analysis of Native and Recombinant Myocilin in Human Trabecular Meshwork Cells and Supermatants. Investigative Ophthalmology & Visual Science 43: U231-U231.
20. Lamb, L. E., J. D. Simon, and B. S. McKay. 2002. Coordinated Stimulation of Cell Junctions and Pigmentation in Human RPE Cells. Investigative Ophthalmology & Visual Science 43: U1303-U1303.
21. McKay, B. S., W. Bao, and G. K. Klintworth. 2002. Expression of Recombinant Transforming Growth Factor Beta Inducible Protein in Insect Cells. Investigative Ophthalmology & Visual Science 43: U381-U381.
22. Stamer, W., G. J. Jaffe, and B. S. McKay. 2002. Expression of Aquaporin-1 Protein in Human Retinal Pigment Epithelium. Investigative Ophthalmology & Visual Science 43: U1302-U1302.
23. Yang, P., W. L. Roberts, J. B. Allen, B. S. McKay, and G. J. Jaffe. 2002. The Effect of Adenovirus-Mediated Civerexpression of Mutant I Kappa B on Il-I Beta-Induced Nf-Kappa B Activation in Cultured Human RPE Cells. Investigative Ophthalmology & Visual Science 43: U1291-U1291.
24. McKay, B. S. 2003. Tissue Specific Protein Expression in Cultured Adult Human Rpe. Investigative Ophthalmology & Visual Science 44: U76-U76.
25. Yang, P., B. S. McKay, J. B. Allen, and G. J. Jaffe. 2003. Resistance to Tnf-Alpha-Induced Cell Death by Overexpressing Mutant I Kappa B in Human RPE Cells. Investigative Ophthalmology & Visual Science 44: U83-U83.
26. Conley, S. M., B. S. McKay, and W. D. Stamer. 2004. Selenium Effects on Integrin Activity and Intracellular Signaling in Trabecular Meshwork Cells. Investigative Ophthalmology & Visual Science 45: U440-U440.
27. Hardy, K. M., E. A. Hoffman, B. S. McKay, and W. D. Stamer. 2004. Biochemical Properties of Extracellular Myocilin. Investigative Ophthalmology & Visual Science 45: U188-U188.
28. Hoffman, E. A., A. Poncius, B. S. McKay, and W. D. Stamer. 2004. Cell Cycle Synchronization and Transfection Efficiency of Human Trabecular Meshwork Cells. Investigative Ophthalmology & Visual Science 45: U443-U443.
29. McKay, B. S., E. Erbe, D. Rak, and S. Sherman. 2004. Pigmenting RPE Secrete Neurotrophic Agents. Investigative Ophthalmology & Visual Science 45: U310-U310.
30. Rak, D. J., and B. S. McKay. 2004. Interaction between Oa1 and Beta-Arrestin. Investigative Ophthalmology & Visual Science 45: U191-U191.
31. Stamer, W., D. J. Rak, and B. S. McKay. 2004. Coiled-Coil Interactions of Native Myocilin. Investigative Ophthalmology & Visual Science 45: U187-U187.
32. Yu, L., U. Kelly, J. N. Ebright, G. Malek, B. S. McKay, and C. B. Rickman. 2004. Characterization of Prl-1, a Human Cone Photoreceptor Protein Tyrosine Phosphatase. Investigative Ophthalmology & Visual Science 45: U529-U529.
33. Hoffman, E. A., S. M. Conley, B. S. McKay, and W. D. Stamer. 2005. Role of DNase I in Transfection Efficiency of Human Trabecular Meshwork Cells. Investigative Ophthalmology & Visual Science 46.
34. Kelly, U. L., L. Yu, B. S. McKay, and C. B. Rickman. 2005. Characterization of the Cone Photoreceptor-Associated Protein, Fash3b. Investigative Ophthalmology & Visual Science 46.
35. Whiting, C. J., D. J. Rak, and B. S. McKay. 2005. Neurotrophic Factor Secretion by Pigmenting RPE. Investigative Ophthalmology & Visual Science 46.
36. Yu, L., U. Kelly, J. N. Ebright, G. Malek, B. S. McKay, and C. B. Rickman. 2005. Light Dependent Membrane Association of Prl-1, a Phosphatase Expressed in Cone Photoreceptors. Investigative Ophthalmology & Visual Science 46.
37. Kinnick, T. R., J. B. Stanton, B. Bakall, B. S. McKay, and A. D. Marmorstein. 2006. Accumulation of Lipofuscin in Response to Phagocytosis of Photoreceptor Outer Segments in Fetal Human RPE Cells. Investigative Ophthalmology & Visual Science 47.
38. Sherman, S. J., B. Goodman, T. Falk, and B. S. McKay. 2006. Retinal Pigment Epithelial Cell Transplantation Could Provide Trophic Support in Parkinson's Disease: Results from an in Vitro Model System. Movement Disorders 21: S400-S401.
39. Yu, L., U. L. Kelly, J. N. Ebright, G. Malek, B. S. McKay, V. Y. Arshavsky, and C. Bowes-Rickman. 2006. Oxidative Stress-Induced Expression and Modulation of a Tyrosine Phosphatase Prl-1 in Retina Investigative Ophthalmology & Visual Science 47.
40. Teeple, R. C., V. M. Lopez, and B. S. McKay. 2007. Endogenous OA1 is Distributed to the Apical Surface in RPE. Investigative Ophthalmology & Visual Science 48.
41. Decatur, C. L., V. M. Lopez, W. D. Stamer, R. M. Lynch, and B. S. McKay. 2008. L-DOPA is the Endogenous Ligand for Oa1. Investigative Ophthalmology & Visual Science 49.
42. Congrove NR, Decatur CL, Stanton JB, Marmorstein AD, McKay B.S. (2011) Characterization of Transgenic Mouse RPE Cultures. Investigative Ophthalmology & Visual Science 52.
43. McKay, B.S., Congrove, NR, Dismuke, WD, Stamer, WD. (2013) A Role for Myocilin in Receptor Endocytosis. Investigative Ophthalmology & Visual Science 54.
44. Bowen, TJ, Congrove, NR, Stamer, WD, McKay, B.S. (2014) Myocilin Mutations Alter GPCR Endocytosis. Investigative Ophthalmology & Visual Science 55.
45. Locke, CL, Congrove, NR, Stamer, WD, McKay, B. S. (2014) Myocilin is constitutively released with exosomes from RPE in situ. Investigative Ophthalmology & Visual Science 55.
46. Locke, CL, Dismuke WD, Stamer, WD, McKay, B.S. (2015) Effect of L-DOPA and Dopamine on exosome release from the RPE and Ciliary Body. Investigative Ophthalmology and Vision Science 56.
47. Vaziri, K. Schwartz, SG, Connor, TB, Moshfegh, AA, Moshfeghi, DM, Kishor, KS, Flynn, HW, Carroll, J, Brilliant, MH, McKay, B.S. (2015) Inverse Association Between L-DOPA and Age-Related Macular Degeneration. Investigative Ophthalmology and Vision Science 56.
Press: ARVO Press Room: Posted: 5/5/2015 Parkinson’s treatment may protect against AMD.
VisionAware Blog May 14, 2015. Can a Drug to Treat Parkinson's Disease Also Prevent AMD?
48. Figueroa, A.G., Congrove, N.R., Sillik, S. A., Sadideen, D.T., Falk, T., Bowes Rickman, C. McKay, B.S. (2018) Exosome uptake is selective but not species or tissue-specific. Investigative Ophthalmology and Vision Science 56. Published abstract for the Association for Research in Vision and Ophthalmology Conference May 2018.
49. Piechowicz, M., Figueroa, A.G., Congrove, N.R., Sillik S.A., McKay, B.S. (2018) L-DOPA activation of GPR143 decreases lysosomal pH in RPE. Investigative Ophthalmology and Vision Science 56. Published abstract for the Association for Research in Vision and Ophthalmology Conference May 2018.
50. McKay, B.S., Sillik, S.A., Dismuke, W.M., Locke, C.J., Congrove, N.R., Stamer, W.D. (2018). “Endosomal Function and Glaucoma”. XXIII Biennial Meeting of the International Society for Eye Research, Belfast, Northern Ireland, UK. September 2018.
51. McKay. B.S., Congrove, N.R., Figueroa, A.G., Sillik, S.A. (2018). “GPR43 Signaling and Retinal Degeneration”. XVIII International Symposium on Retinal Degeneration (2018) Killarney, Ireland September 2018.
52. Rory Morrison-Colvin, Sara A Sillik, Nicole R. Congrove, Brian S. McKay, Robert W. Snyder “Circadian Patterns of Secretion of VEGF by RPE” Investigative Ophthalmology and Vision Science 57. Published abstract for the Association for Research in Vision and Ophthalmology Conference May 2019.
53. Brennan Michael Boyd, Timothy Fagan, Anna G. Figueroa, Brian S. McKay, Robert W. Snyder. “Short Term Effects of Carbidopa-Levodopa in Neovascular AMD”. Investigative Ophthalmology and Vision Science 57. Published abstract for the Association for Research in Vision and Ophthalmology Conference May 2019.
54. Anna G. Figueroa, Nicole R. Congrove, Yutao Liu, Brian S. McKay. “Dopaminergic control of constitutive exosome release from in situ RPE”. Investigative Ophthalmology and Vision Science 57. Published abstract for the Association for Research in Vision and Ophthalmology Conference May 2019.
55. Brian S. McKay. “Parkinson drug may prevent and delay AMD”. Investigative Ophthalmology and Vision Science 57. Published abstract for the Association for Research in Vision and Ophthalmology Conference May 2019.
56. Anna G. Figueroa; Nicole Congrove; Brian S McKay. Stress-induced in situ RPE Exosome Release. Investigative Ophthalmology and Vision Science 61. Published abstract for the Association for Research in Vision and Ophthalmology Conference May 2020.
57. Sara Ann Sillik; Rory Morrison-Colvin; Nicole Congrove; Brian S McKay; Robert W Snyder. Circadian secretion of VEGF and PEDF in Polarized RPE. Investigative Ophthalmology and Vision Science 61. Published abstract for the Association for Research in Vision and Ophthalmology Conference May 2020.
58. John Paul SanGiovanni, Daniel Q. SanGiovanni, Robert W. Snyder, Dawn L. Geiser, Brian S. McKay. “Differential Expression Patterns of Genes Encoding Monoamine Pathway Constituents Exist in Retinal Specimens of People with Neovascular AMD. Investigative Ophthalmology and Vision Science 62 Published abstract for the Association for Research in Vision and Ophthalmology Conference May 2021.
59. Dorothy Tung; Brandon Good; Anna Figueroa; Nicole Congrove; Brian S. McKay. GPR143 Signaling Alters Intracellular Trafficking of POS. Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1797 – F0346. doi:
60. Bohan Xing, Remington Bliss, Leila Jamal, Burke Lieppman, Brian S. McKay, Xuemin Zhang Exosome Isolation from Human Tears. Investigative Ophthalmology & Visual Science June 2023, Vol.64.
61. Tawanda Zvavamwe, Dorothy Tung, Nicole R. Congrove, Brian S. McKay. GPR143 Signaling Alters Endosomal Trafficking of Outer Segments. Investigative Ophthalmology & Visual Science June 2023, Vol.64.
62. Remington M. Bliss, Nicole R. Congrove, Induvahi Veernala, Brian S, McKay.
Hypoxic Influence on Human Melanocyte Extracellular Vesicle Release. Investigative Ophthalmology & Visual Science June 2024, Vol.65.
63. Induvahi Veernala1, Nicole R. Congrove1, Remington M Bliss2, Brian S. McKay.
Potential Role of Extracellular vesicles in Angiogenesis and Age-Related Macular Degeneration. Investigative Ophthalmology & Visual Science June 2024, Vol.65.
64. Ghosh, Arko, Bliss, Remington M., Panjwani, Meet, Holmes, Jonathan M.,
McKay, Brian S. Tear exosomes and age-related macular degeneration. Investigative Ophthalmology & Visual Science June 2024, Vol.65.
65. Yañez, Serena R.; Congrove, Nicole R.; McKay, Brian S. Extracellular Vesicle Release
by Human.Melanocytes: Implications for AMD Pathogenesis. Investigative Ophthalmology & Visual Science June 2025, Vol.66.
66. Ghahari, Parichehr ; Congrove, Nicole ; Ghahari, Elham ; Yanez, Serena ; Vazquez
Luna, Lane ; Kozak, Igor ; Panjwani, Meet ; McKay, Brian S. Differential Effects of Hypoxia on Extracellular Vesicle Concentration and Size in Porcine and Human Trabecular Meshwork Cells. Investigative Ophthalmology & Visual Science June 2025, Vol.66.
67. Joseph Adams, Yogesh Sutar, Induvahi Veernala, Brian S. McKay, Abhijit A. Date.
L-DOPA self-assembled nanoparticles for the topical treatment of age-related
macular degeneration. Investigative Ophthalmology & Visual Science June 2025,
Vol.66.

RPE Trophic Activity for Retinal Protection. PI: McKay, BS.
NEI R01 EY026544-01 Dates: 3/1/17-2/28/22. Direct Costs $225,000 per year.
The primary goal of this project is to determine whether GPR143 signaling ensures survival of retinal neurons during the aging process.